Antiplatelets : Medicines like Aspirin, Clopidogrel (or Prasugrel or Ticagrelor) need to be started before angioplasty. Aspirin is to be continued for the entire lifespan while Clopidogrel needs to be continued compulsorily for at least 3 to 12 months unless contraindicated. If these medicines are discontinued even by mistake, there is a serious risk of accumulation of blood clot inside the stent leading to heart attack or death.
Glycoprotein Receptor Blocker : Medicines like Abciximab, Tirofiban and Intigrilin are used during angioplasty in situations of heart attack or in presence of very thick blood/ multiple blood clots. These medicines are given through a vein (intravenous) during initial few hours. These medicines are double-edged sword and may cause severe bleeding in few cases. Its use has been declining after availability of better oral antiplatelet medicines.
Heparin/Bivalirudin : These intravenous anticoagulant medicines are compulsory during angioplasty in all cases. These medicines are comparatively safe and their dose can be increased or decreased based on a blood test called as ACT.
Statin : When given in high doses, this medicine reduces cholesterol levels very rapidly and drastically. It reduces inflammation (swelling) of arteries and as a result, the possibility of re-heart attack is significantly reduced. Atorvastatin (80 mg/day) or Rosuvastatin (40 mg/day) are two powerful drugs. These medicines are considered a revolutionary invention. It is necessary to take these medicines for the entire lifespan.
Besides this, it is also necessary to take Beta-blocker, an ACE Inhibitor, Nitrate, Calcium channel blocker, etc. Medicines as per requirement.