International Clinical Trials
1 | Co – Investigator for RUBY registry (For India) (2002) | To evaluate Percusurge / Guardwire Distal Protection Device (Presented by Dr. Aman, Switzerland) | Trial completed |
2 | Co – Investigator at Sterling Hospital for Extract-TIMI 25 Multicentre multinational Trial (2003) | Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment Thrombolysis in Myocardial Infarction – Study 25. | Trial completed |
3 | Co – Investigator for OASIS-5 Trial (2004) | To evaluate the efficacy and safety of fondaparinux versus Enoxaparin in the acute treatment of unstable angina or non ST-segment elevation myocardial infarction acute coronary syndromes. | Trial completed |
4 | Co – Investigator for OASIS-6 Trial (2004) | To evaluate the efficacy and safety of fondaparinux sodium versus control therapy and Glucose-Insulin-Potassium infusion versus control in broad range in patients with ST – segment elevation acute myocardial infarction. | Trial completed |
5 | Co – Investigator for TRUST Trial (2004) | To evaluate the safety and efficacy of intravenous Remodulin® in patients( in India) With Pulmonary arterial hypertension (PAH) in 12-week. | Trial completed |
6 | Co – Investigator for Paediatric Hypertension Trial (2005) | Dose ranging study to evaluate the safety and efficacy of Olmesartan medoxomil in children and adolescents with hypertension. | Trial completed |
7 | Co – Investigator for Hypercholesterol study (NK-104-301) at The Heart Care Clinic (2005) | Study of Pitavastatin 2 mg vs. Atorvastatin 10 mg and Pitavastatin 4 mg vs. Atorvastatin 20 mg (Following Up Titration) in Patients with Primary Hypercholesterolemia Or Combined Dyslipidemia. | Trial completed |
8 | Co – Investigator for Neovasc Reducer™ Pilot Study, First in human: (2005) | To evaluate the safety of the Neovasc Reducer™ in the treatment of Ischemic heart Disease (IHD), controlled narrowing of the coronary sinus. | Trial completed |
9 | Co – Investigator For PAPIRUS Trial: Pilot Study, First in Human: Apollo Hospital (2005) | Monitoring Pulmonary Artery Pressure by Implantable Device Responding to Ultrasonic Signal(REMON Device) | Trial completed |
10 | Co – Investigator for Export study (2006) | Flow improvement in patients with Acute Myocardial Infarction undergoing either conventional stenting or a strategy of primary aspiration followed by stenting using the Export® Aspiration Catheter: a Prospective, Randomized, Controlled Study. | Trial completed |
11 | Co – Investigator for E-five registry (for India) (2006) | To Evaluate the ‘Real World’ Clinical Performance of the Medtronic Endeavor™ ABT-578 Eluting Coronary Stent System. | Trial completed |
12 | Co – Investigator for RELY study (2006) | Randomized Evaluation of Long term anticoagulant therapycomparing efficacy and safety of two blinded doses of dabigatran etexilate with open label warfarin for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation: prospective, multi-centre, Parallel group, non-inferiority trial. | Trial completed |
13 | Co – Investigator for Hypercholesterolemia study (NK-104-307) at The Heart Care Clinic (2006) | Open label, long-Term (1year) extension study of Pitavastatin 4 mg QD in patients with Primary Hypercholesterolemia or combined Dyslipidemia. | Trial completed |
14 | Co – Investigator for e-SELECT Registry (2007) | The e-SELECT Registry: A Multicenter Post Marketing Survelliance. | Trial completed |
15 | Co – Investigator for Early ACS trial (2007) | Early Glycoprotein Iib/IIIa Inhibition in Non-ST-segment Elevation Acute Coronary Syndrome: A Randomized, Placebo-Controlled Trial Evaluating the Clinical Benefits of Early Front-loaded Eptifibatide in the Treatment of Patients with Non-ST-segment Elevation Acute Coronary Syndrome (EARLY ACS) | Trial completed |
16 | Principal – Investigator for PLATO trial (2007) | A Randomised, Double-blind, Parallel Group, Phase 3, Efficacy and safety study of AZD6140 Compares with Clopidogrel for prevention of Vascular Events in patients with Non-ST or ST Elevation Acute Coronary Syndromes (ACS) [PLATO – A study of PLATelet inhibition and Patient Outcomes.] | Trial completed |
17 | Co – Investigator for OASIS- 7 trial (2007) | Randomized, multinational, double-blind study, comparing a high loading dose regimen of Clopidogrel versus standard dose in patients with unstable angina or non-ST segment elevation myocardial infarction managed with an early invasive strategy. | Trial completed |
18 | Co – Investigator for New Guidewire (2007) | First in Man: A Feasibility study to evaluate safety and efficacy of New Guidewire for Crossing Total Occlusions in Coronary Arteries. | Trial completed |
19 | Co – Investigator for Paediatric Hypertension Trial, The Heart Care Clinic, Ahmedabad (2007) | A Randomized, double blind, Placebo-Controlled, Multicenter, Parallel Study Assessing the Efficacy, Safety, and Dose Response of Ramipril for the Treatment of Hypertension in Children and Adolescents. | Trial completed |
20 | Co – Investigator for Aristotle Trial at The Heart Care Clinic, Ahmedabad (2007) | Apixaban for reduction in stroke and other thromboembolic events in atrial fibrillation: Active controlled randomized double blind parallel arm study to evaluate efficacy and safety of Apixaban in subject with non valvular Atrial fibrillation. | Follow-ups ongoing |
21 | Co – Investigator for Rocket Trial at The Heart Care Clinic, Ahmedabad (2007) | Multicenter, Randomized, double-blind – dummy, Parallel-group, Non-inferiority Trial Comparing the Efficacy and Safety of Once-daily oral Rivaroxabab (BAY 59-7939) with Adjusted-dose oral Warfarin for the prevention of Stroke and Non-central-nervous-system systemic embolism in Subjects with Non-valvular Atrial Fibrillation. | Follow-ups ongoing |
22 | Co – Investigator for PROTECT Trial (2007) | Patient Related Outcomes with Endeavor versus Cypher stenting Trial: Prospective, multicenter, randomized, two-arm, open-label trial. | Follow-ups ongoing |
23 | Co – Investigator for TMC-CAN-05-02 (2007) | A clinical trial comparing Cangrelor to Clopidogrel in subject who require Percutaneous Coronary Intervention. | Follow-ups ongoing |
24 | Co – Investigator for TMC-CAN-05-03 (2008) | A clinical Trial comparing treatment with Cangrelor (in combination with usual care) to usual care in subjects who require Percutaneous Coronary Intervention. | Follow-ups ongoing |
25 | Co – Investigator for CL (Ivabradine) at The Heart Care Clinic (2008) | Evaluation of the anti-anginal efficacy. | Follow-ups ongoing |
26 | Co – Investigator for RE-DEEM at The Heart Care Clinic (2008) | Randomized Dabigatran Etexilate dose finding study in patients with acute coronary syndromes post index Event with additional risk factors for cardiovascular complications also receiving aspirin and clopidogrel: Multi-centre, prospective, placebo controlled, group dose escalation trial. | Trial completed |
27 | Co – Investigator for Magellan Trial (2008) | A Multicenter, Randomized, parallel-group efficacy superiority study in hospitalize medically ill patients comparing rivaroxaban with Enoxaparin. | Follow-ups ongoing |
28 | Co – Investigator for Borealis Trial at The Heart Care Clinic Ahmedabad (2008) | A multicenter, randomized, double-blind, assessor-blind, non-inferiority study comparing the efficacy and safety of once-weekly subcutaneous biotinylated idraparinux (SSR126517E) with oral adjusted-dose warfarin in the prevention of stroke and systemic thromboembolic events in patient with atrial fibrillation. | Trial completed |
29 | Co – Investigator for Freedom-PAH at The Heart Care Clinic | FREEDOM UT – 15C Studies (TDE-PH-302 and TDE-PH-304) conducted by United Therapeutics. | Ongoing |
30 | Co – Investigator for ORBIT – 1 | Pilot study to evaluate the safety & performance or the diamond back 360TM orbit Atherectomy system in treating de-NOVO calcified coronary lesions – orbit -1. | Trial completed |
31 | Co – Investigator for AVERROES at The Heart Care Clinic | CV 185-048: A Phase 3, Active (Aspirin) Controlled, Randomized, Double-Blind, Parallel arm Study to Evaluate the Efficacy and Safety of Apixaban in Preventing Stroke and Systemic Embolism in Patients with Nonvalvular Atrial Fibrillation. | Trial completed |
32 | Co – Investigator for Red-HF at The Heart Care Clinic | A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Assess the Efficacy and Safety of Darbepoetin alfa Treatment on Mortality and Morbidity in Heart Failure (HF) Subjects with Symptomatic Left Ventricular Systolic Dysfunction and Anemia – 20050222 Amendment 1. | Ongoing |
33. | Co – Investigator for TAK-442-202 at The Heart Care Clinic | A Phase II, double-blind, Randomized, Placebo-controlled study of the safety and Efficacy of TAK-442 in subjects with Acute Coronary Syndrome. | Trial completed |
34. | Co – Investigator for EISAI-202 at The Heart Care Clinic | A Randomized, Double-Blind Placebo controlled study of the safety and tolerability of E5555 and its effect on clinical event and biomarkers in patient with Non ST segment Elevation Acute Coronary Syndrome. | Trial completed |
35 | Co – Investigator for E-Resolute at the Heart Care Clinic | Evaluation of the Endeavor Resolute Zolarolumes-Eluting Coronary Stent System in a ‘Real World’ Patient Population. | Follow-up ongoing |
36 | Co – Investigator of RIVAROXABAN at The Heart Care Clinic | Randomized, Double Blind, Placebo Controlled, Event Driven, Multi Center Study To Evaluate The Efficacy And Safety Of Rivaroxaban In Subjects With Recent ACS. | Follow-up ongoing |
37 | Co – Investigator of Pfizer PAH at The Heart Care Clinic B1321001 | A Phase 3, Multi Center, Randomized, Double Blind, Placebo Controlled, Safety And Efficacy Study Of Sitaxsentan Sodium In Subjects With Pulmonary Arterial Hypertension. | Ongoing |
38 | Co – Investigator of Pfizer PAH at The Heart Care Clinic B1321002 | A Phase 3, Multi Center, Open Label Study To Evaluate The Long Term Safety Of Monotherapy Sitaxsentan Sodium And Combination Therapy With Sitaxsentan Sodium And Sildenafil Citrate In Subjects With Pulmonary Arterial Hypertension. | Ongoing |
39 | Co – Investigator of Pfizer PAH at The Heart Care Clinic B1321003 | A Phase 3, Multi Center, Randomized, Double Blind, Efficacy And Safety Study Of Monotherapy Sitaxsentan Sodium Versus Combination Therapy With Sitaxsentan Sodium and Sildenafil Citrate In Subjects With Pulmonary Arterial Hypertension Who Have Completed Study B1321001. | Ongoing |
40 | Co – Investigator of LPL STABILITY at The Heart Care Clinic | A Clinical Outcome Study Of Darapladib Versus Placebo In Subjects With Chronic Coronary Heart Disease To Compare The Incidence Of Major Adverse Cardiovascular Event. (MACE) | Follow-up ongoing |
41 | Co – Investigator of OASIS-8 at The Heart Care Clinic | A Prospective Study Evaluating The Safety Of Two Regimens Of Adjustive Intravenous UFH PCI In High Risk Patients With UA/NSTEMI Initially Treated With Subcutaneous Fondaparinux And Referred For Early Coronary Angiography. | Follow-up ongoing |
42 | Co – Investigator of STEM CELL | A Randomized, Double Blind, Multi Centric, Placebo Controlled, Single Dose, Phase I/II Study Assessing The Safety And Efficacy Of Intravenous Ex Vivo Cultured Adult Allogenic Mesenchymal Stem Cell In Patients With ST Elevated Acute MI (STEMI) Patient. | Follow-up ongoing |
44 | Co – Investigator for RUBY 1 Trial at The Heart Care Clinic Ahmedabad (2010) | A Randomized, Double Blind, Placebo Controlled, Multi Center and Parallel Group Study of the Safety, Tolerability, and Efficacy of YM150 in combination with Standard Treatment in Secondary Prevention of Ischemic Vascular Events in Subjects with Acute Coronary Syndromes. | Follow-up ongoing |
45 | Co – Investigator for AmarinTrial at The Heart Care Clinic Ahmedabad (2010) | A phase 3, multicenter, placebo controlled, randomized, double blind, 12 week study with an open label extension to evaluate the efficacy And safety of AMR101 in patients with fasting triglyceride levels > 500 mg/dl and < 2000 mg/dl. | Follow-up ongoing |
46 | Co – Investigator for SASHF RTrial at The Heart Care Clinic Ahmedabad (2008) | South Asian Systolic Heart Failure Registry. | Ongoing |
47 | Co – Investigator for TRAC HF Trial at The Heart Care Clinic Ahmedabad (2009) | TRAC HF: Ambulatory Monitoring Using External Physiological Sensors in Heart Failure Patients. | Ongoing |
48 | Co – Investigator for Alecardio trial at CIMS hospital | Cardiovascular outcomes study to evaluate the potential of aleglitazar to reduce reduce cardiovascular risk in patients with recent acute coronary syndrome (ACS) event and type 2 diabetes mellitus (T2D) | Ongoing |
49 | Co – Investigator for Timi 52 trial at CIMS hospital | A Clinical Outcomes Study of Darapaladib versus Pleacebo in Subjects Following Acute Coronary Syndrome to Compare the Incidence of Major Adverse Cardiovascular Events (MACE) | Ongoing |
50 | Co – Investigator for Resolute Asia trial at CIMS hospital | Evaluation of the Endevor Resolute Zotarolimus-Eluting Coronary Stent System in a Patient Population with Long Lesion(s) aand/or Dual Vessels in Asia; Prospective, Multi-center, Non-randomized Study. | Ongoing |
51 | Co – Investigator for Appraise-2 trial | A Phase 3, Randomized, Double-blind, Evaluation of the safety and Efficacy of Apixaban in subjects with a Recent Acute Coronary Syndrome. | Follow-up ongoing |
National Clinical Trials
| 1 | Co – Investigator for BIVAFLO Registy (2006) | To evaluate the efficacy and safety of BIVAFLO® as an adjunctive therapy during PCI in moderate-high risk ACS patients with provisional GP IIb/IIIa inhibitors use. | Trial completed |
| 2 | Co – Investigator for CORREL + C Trial (2006) | The COREL C Registry: A multicentre Post marketing Survelliance for clinical and angiographic evaluation of Corel C stent. | Trial completed |
| 3 | Principal Investigator for POLYCAP Trial at VS hospital Ahmedabad(2007) | A randomized double blind controlled trial of the efficacy And safety of POLYCAP Vs its components in subjects With atleast one additional cardiovascular risk factor. | Trial completed |
| 4 | Co – Investigator for ACUNOVA Trial (2006-2007) | A phase III, open label, multicentric, parallel group, Randomized study to evaluate the safety and efficacy of Abciximab in Indian patients scheduled for Percutaneuos Coronary Intervention. | Trial completed |
| 5 | Co – Investigator for ZYHI Trial at The Heart Care Clinic Ahmedabad (2007). | (1) A randomized, double blind parallel group, prospective dose ranging study of ZYH 1 with an open fenofibrate arm to evaluate the efficacy on dyslipidemia in patients without diabetes Protocol No. 2001 Ver: 01 (2) A randomized, double blind parallel group, prospective dose ranging study of ZYH1 with an open pioglitazone arm to evaluate the efficacy on dyslipidemia in patients with diabetes Protocol No. 2003 Ver: 02 (3) A randomized, double blind parallel group, prospective dose ranging study of ZYH 1 with an open pioglitazone arm to evaluate the efficacy on dyslipidemia in patients with impaired glucose test Protocol No.2004 Ver: 02. | Trial completed |
| Dr. Anish Chandarana, MD, DM (Cardiology, Gold Medalist) – Senior Cardiologist at CIMS Hospital in Ahmedabad, Gujarat, India +91 9825096922. |
| Based on the above merits, accomplishments, and detailed resume, as well as from patient feedback across many years, Dr. Anish Chandarana is considered as one of the best cardiologists in Ahmedabad, Gujarat and India. |
